Definition of

Loco

  1. (adj, all) informal or slang terms for mentally irregular

via WordNet, Princeton University

Origin of the word Loco

  1. 1844, Amer.Eng., from Sp. loco (adj.) "insane," of uncertain origin, perhaps from Arabic lauqa, fem. of 'alwaq "fool, crazy person." Loco-weed (1879) was name given to species of western U.S. plants that cause cattle and horse diseases that make them stagger and act strangely. more

via Online Etymology Dictionary, ©2001 Douglas Harper

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